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POU2AF1 抗体 (AA 1-100)

This anti-POU2AF1 antibody is a 兔 多克隆 antibody detecting POU2AF1 in WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 和 ICC. Suitable for 人.
产品编号 ABIN1714116
发货至: 中国

Quick Overview for POU2AF1 抗体 (AA 1-100) (ABIN1714116)

抗原

See all POU2AF1 抗体
POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))

适用

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  • 20
  • 5

宿主

  • 66
  • 9
  • 2

克隆类型

  • 63
  • 14
多克隆

标记

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  • 4
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  • 2
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  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This POU2AF1 antibody is un-conjugated

应用范围

  • 48
  • 27
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Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
  • 抗原表位

    • 15
    • 14
    • 11
    • 6
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 1-100

    预测反应

    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human BOB1

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))

    别名

    BOB1

    背景

    Synonyms: B cell Oct binding protein 1, B cell specic coactivator OBF 1, B cell specic coactivator OBF1, B-cell-specic coactivator OBF-1, BOB 1, BOB-1, OBF 1, OBF1, OBF1_HUMAN, OCA B, OCA-B, OCAB, OCT binding factor 1, OCT-binding factor 1, POU domain class 2 associating factor 1, POU domain class 2-associating factor 1, POU2AF1.

    Background: POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. The POU dimer from the OCT1 gene formed on the palindromic OCT factor recognition element, or PORE (ATTTGAAATGCAAAT), could recruit the transcriptional coactivator OBF1. Studies of tissue-specific expression of immunoglobulin promoters demonstrate the importance of an octamer, ATTTGCAT, and the proteins that bind to it. This is a regulatory element important for tissue- and cell-specific transcription as well as for transcription of a number of housekeeping genes. Oct-1 encodes one protein, NF-A1, which is found in nuclear extracts from all cell types and thus is not specific to lymphoid cells as is the protein NF-A2, which is encoded by Oct-2. A novel protein designated Bob 1 (B cell Oct binding protein 1), alternatively called OBF-1, specifically interacts with Oct-1 and Oct-2, enhancing their transcriptional efficacy. Bob 1 is expressed at highest levels in spleen and peripheral blood leukocytes and represents an Oct co-factor capable of conferring cell-specific activation of Oct-1 and Oct-2. Although having no intrinsic capacity for DNA binding, Bob 1 associates tightly with the octamer motif in the presence of Oct-1 and/or Oct-2. The gene which encodes Bob 1 maps to human chromosome 11q23.1.

    基因ID

    5450
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