FZD4 抗体 (PE-Cy7)
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北京 101111
Quick Overview for FZD4 抗体 (PE-Cy7) (ABIN1713249)
抗原
See all FZD4 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
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亚型
- IgG
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anti-Frizzled Family Receptor 4 (FZD4) (AA 37-222) antibody
FZD4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2F3A7 unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (Middle Region) antibodyFZD4 适用: 人, 小鼠, 大鼠, Cow, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) antibodyFZD4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (AA 37-222) antibodyFZD4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (AA 107-206) antibodyFZD4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G7 unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (C-Term) antibodyFZD4 适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 小鸡, 马, 豚鼠, 猴, Bat, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (C-Term) antibodyFZD4 适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 小鸡, 马, 猴, Hamster, Bat, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (N-Term) antibodyFZD4 适用: 人, 大鼠, Cow, 犬, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) (AA 151-250) antibodyFZD4 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 4 (FZD4) antibodyFZD4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM(1:100-500)
Optimal working dilution should be determined by the investigator. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FZD4 (Frizzled Family Receptor 4 (FZD4))
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别名
- Frizzled 4/CD344
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背景
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Synonyms: Fz4, EVR1, FEVR, Fz-4, FzE4, GPCR, hFz4, CD344, FZD4S, Frizzled-4, FZD4
Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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基因ID
- 8322
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UniProt
- Q9ULV1
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途径
- WNT signaling, Hormone Transport, Sensory Perception of Sound
抗原
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