Cytohesin 2 抗体 (AA 21-120) (Cy7)
Quick Overview for Cytohesin 2 抗体 (AA 21-120) (Cy7) (ABIN1707978)
抗原
See all Cytohesin 2 (CYTH2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-120
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Dog,Sheep,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Cytohesin 2
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亚型
- IgG
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anti-Cytohesin 2 (CYTH2) (AA 314-398) antibody
CYTH2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Cytohesin 2 (CYTH2) (AA 1-390) antibodyCYTH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytohesin 2 (CYTH2) (AA 150-350) antibodyCYTH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytohesin 2 (CYTH2) (AA 1-400) antibodyCYTH2 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytohesin 2 (CYTH2) (N-Term) antibodyVerified CYTH2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cytohesin 2 (CYTH2) antibodyCYTH2 适用: 人, 大鼠, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Cytohesin 2 (CYTH2) (AA 314-398) antibodyCYTH2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E11 unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Cytohesin 2 (CYTH2)
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别名
- Cytohesin 2
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背景
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Synonyms: ARF exchange factor, ARF nucleotide binding site opener, Arno, ARNO protein, CLM2, CTS18, CTS18.1, Cyth2, Cytohesin 2, MGC137537, MGC80440, PH, SEC7 and coiled-coil domain-containing protein 2, Pleckstrin homology Sec7 and coiled coil domains 2, Pleckstrin homology Sec7 and coiled coil domains protein 2, PSCD2, PSCD2L, PSCD2L, formerly, Sec7, SEC7 homolog B, Sec7B, SEC7L, Sec7p L, Sec7p-like, Sec7pL, CYH2_HUMAN.
Background: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf?s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).
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基因ID
- 9266
抗原
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