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Cytohesin 2 抗体 (AA 21-120)

CYTH2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1714087
发货至: 中国
  • 抗原 See all Cytohesin 2 (CYTH2) 抗体
    Cytohesin 2 (CYTH2)
    抗原表位
    • 14
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-120
    适用
    • 31
    • 19
    • 18
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 39
    • 3
    • 1
    克隆类型
    • 41
    • 2
    多克隆
    标记
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cytohesin 2 antibody is un-conjugated
    应用范围
    • 42
    • 19
    • 12
    • 12
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    人, 大鼠
    预测反应
    Mouse,Dog,Sheep,Pig,Horse,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Cytohesin 2
    亚型
    IgG
    Top Product
    Discover our top product CYTH2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    Cytohesin 2 (CYTH2)
    别名
    Cytohesin 2 (CYTH2 产品)
    别名
    ARNO antibody, CTS18 antibody, CTS18.1 antibody, PSCD2 antibody, PSCD2L antibody, SEC7L antibody, Sec7p-L antibody, Sec7p-like antibody, CLM2 antibody, Pscd2 antibody, Arno antibody, Sec7 antibody, Sec7B antibody, pscd2 antibody, MGC84366 antibody, CYTH2 antibody, cyth2 antibody, cytohesin 2 antibody, cytohesin-2 antibody, cytohesin 2 L homeolog antibody, si:dkey-283b15.4 antibody, CYTH2 antibody, PTRG_08834 antibody, Cyth2 antibody, cyth2.L antibody, cyth2 antibody, si:dkey-283b15.4 antibody
    背景

    Synonyms: ARF exchange factor, ARF nucleotide binding site opener, Arno, ARNO protein, CLM2, CTS18, CTS18.1, Cyth2, Cytohesin 2, MGC137537, MGC80440, PH, SEC7 and coiled-coil domain-containing protein 2, Pleckstrin homology Sec7 and coiled coil domains 2, Pleckstrin homology Sec7 and coiled coil domains protein 2, PSCD2, PSCD2L, PSCD2L, formerly, Sec7, SEC7 homolog B, Sec7B, SEC7L, Sec7p L, Sec7p-like, Sec7pL, CYH2_HUMAN.

    Background: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf?s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

    基因ID
    9266
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