APLF 抗体 (AA 421-511) (Cy7)
Quick Overview for APLF 抗体 (AA 421-511) (Cy7) (ABIN1707592)
抗原
See all APLF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 421-511
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预测反应
- Human,Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human APLF
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亚型
- IgG
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anti-Aprataxin and PNKP Like Factor (APLF) (Ser116) antibody
APLF 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aprataxin and PNKP Like Factor (APLF) (Ser116) antibodyAPLF 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aprataxin and PNKP Like Factor (APLF) (Internal Region) antibodyAPLF 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aprataxin and PNKP Like Factor (APLF) (Tyr861) antibodyAPLF 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aprataxin and PNKP Like Factor (APLF) (AA 200-380) antibodyAPLF 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Aprataxin and PNKP Like Factor (APLF) (AA 82-131) antibodyAPLF 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- APLF (Aprataxin and PNKP Like Factor (APLF))
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别名
- APLF
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背景
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Synonyms: 2010301N04Rik, AI452191, Aplf, APLF_HUMAN, Aprataxin and pnk-like factor, Apurinic-apyrimidinic endonuclease APLF, C2orf13, PNK and APTX like FHA protein, PNK and APTX-like FHA domain-containing protein, RGD1565557, XIP1, XRCC1 interacting protein 1, XRCC1-interacting protein 1.
Background: APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8 % of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
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基因ID
- 200558
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途径
- DNA Damage Repair
抗原
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