14-3-3 sigma/SFN 抗体 (AA 101-200) (Cy3)
Our Local Distributor
北京 101111
Quick Overview for 14-3-3 sigma/SFN 抗体 (AA 101-200) (Cy3) (ABIN1702896)
抗原
See all 14-3-3 sigma/SFN (SFN) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 101-200
-
交叉反应
- 人, 大鼠
-
预测反应
- Mouse,Dog,Sheep,Pig,Horse,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human 14-3-3 sigma
-
亚型
- IgG
-
-
anti-Stratifin (SFN) antibody
SFN 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Stratifin (SFN) (Internal Region) antibodyVerified SFN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 3C3 unconjugated
anti-Stratifin (SFN) (C-Term) antibodySFN 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-249) antibodySFN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Stratifin (SFN) antibodySFN 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal CPTC-SFN-2 unconjugated
anti-Stratifin (SFN) (AA 140-156), (Middle Region) antibodySFN 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Stratifin (SFN) (AA 222-248), (C-Term) antibodySFN 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB27523 unconjugated
-
-
应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
-
别名
- 14-3-3 sigma
-
背景
-
Synonyms: 14 3 3 protein sigma, 14-3-3 protein sigma, 1433S_HUMAN, Epithelial cell marker protein 1, Er, HME 1, HME1, MGC143283, Mkrn3, Mme1, OTTHUMP00000004242, RP23 137L22.11, SFN, SFN protein, Stratin, YWHAS.
Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
-
基因ID
- 2810
-
途径
- p53 Pathway, Myometrial Relaxation and Contraction
抗原
-
