BCAR1 抗体 (pTyr249) (AbBy Fluor® 555)
Quick Overview for BCAR1 抗体 (pTyr249) (AbBy Fluor® 555) (ABIN1696484)
抗原
See all BCAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr249
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预测反应
- Human
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human BCAR1 around the phosphorylation site of Tyr249
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亚型
- IgG
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anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (AA 1-240) antibody
BCAR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) antibodyBCAR1 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p), IF, FACS 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) antibodyBCAR1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p), IF, FACS 宿主: 小鼠 Monoclonal 3A5 unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (AA 68-218) antibodyBCAR1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (pTyr410) antibodyBCAR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Internal Region) antibodyBCAR1 适用: 人, 小鼠 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Tyr410) antibodyBCAR1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (pTyr410) antibodyBCAR1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Internal Region) antibodyVerified BCAR1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (AA 1-870) antibodyBCAR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
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别名
- BCAR1
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背景
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Synonyms: BCAR1 phospho Y249, BCAR1phospho Y249, p-BCAR1p-Tyr249, Breast cancer anti estrogen resistance 1 protein, BCAR 1, Bcar1, BCAR1_HUMAN, Breast cancer anti estrogen resistance 1, Breast cancer anti-estrogen resistance protein 1, CAS, Cas scaffolding protein family member 1, Crk associated substrate, Crk associated substrate p130Cas, CRK-associated substrate, CRKAS, P130CAS.
Background: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.
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基因ID
- 9564
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
抗原
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