CREB1 抗体 (Ser133)
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Quick Overview for CREB1 抗体 (Ser133) (ABIN1685160)
抗原
See all CREB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Ser133
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纯化方法
- Purified
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过滤
- Sterile filtered
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免疫原
- Polyclonal p-CREB-1 antibody was produced from sera of mice immunized with synthetic protein containing residues surrounding ser133 .
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亚型
- IgG
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应用备注
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ELISA: Use at a concentration range of 1-2 µg/mL.
Western blot: A suitable range of concentrations of this antibody for WB detection is 10 µg/mL. WB analysis mouse hippocampal tissue lysate expressing phospho CREB1. ABIN1685160 was used as primary antibody.
IHC: A suitable range of concentrations of this antibody for IHC is 10 µg/mL. Immunohistochemical analysis of frozen mouse hyppocampal sections expressing CREB1. ABIN1685160 was used as primary antibody, dilution 1:200. Immunohistochemical analysis of FFPE mouse thymocytes expressing phospho CREB-1. ABIN1685160 was used as primary antibody, dilution 1:500. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
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缓冲液
- PBS solution at a concentration of 1 mg/mL.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Recombinant IL-21R, as supplied, can be stored in working aliquots at - 8 °C for one month, or at -20 °C to -70 °C for twelve months.
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有效期
- 12 months
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- CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
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别名
- CREB1
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背景
- The IL-21 receptor (IL-21R) is structurally related to IL-2R and IL-15R. In addition, these receptors, together with IL-4R, IL-7R, and IL-9R, share a common gamma -chain. IL-21R appears in T, natural killer (NK), B, and dendritic cells (DC), and it plays an important role in the regulation and function of these cells. IL-21 has, however, an effect on NK cells depending on their activation state. It enhances the proliferation and cytotoxic activity of activated NK cells, but in these cells, IL-21 also promotes apoptosis and thus limits NK cell response. In contrast, IL-21 inhibits IL-15-induced proliferation and maturation of NK cell precursors
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UniProt
- P16220
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途径
- TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
抗原
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