TP53BP1 抗体
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北京 101111
Quick Overview for TP53BP1 抗体 (ABIN1679832)
抗原
See all TP53BP1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠
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产品特性
- Monoclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthesized peptide derived from human 53BP1
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亚型
- IgG
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anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 574-773) antibody
TP53BP1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6B3E10 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyKD Validated TP53BP1 适用: 人 WB, FACS, IF (p) 宿主: 小鼠 Monoclonal 24GB13320 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyKO Validated TP53BP1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1955-1972), (C-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pSer25), (pSer29) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pThr543) antibodyTP53BP1 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1724-1964) antibodyTP53BP1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1758-1972) antibodyTP53BP1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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别名
- TP53BP1
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背景
- Double-strand break (DSB repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub and histone H4 dimethylated at 'Lys-20' (H4K20me2, two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast, it is not required for classic NHEJ and V(DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.,53BP1, TDRD30, TP53, p202, p53BP1,Cancer,DNA Damage & Repair,Epigenetics & Nuclear Signaling,Protein phosphorylation,Tumor suppressors,Tumor suppressors_p53 pathway,TP53BP1
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分子量
- 450 kDa
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基因ID
- 7158
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UniProt
- Q12888
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途径
- DNA Damage Repair
抗原
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