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FLT1 抗体 (Soluble)

FLT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1589805
发货至: 中国
  • 抗原 See all FLT1 抗体
    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
    抗原表位
    • 16
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    Soluble
    适用
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    宿主
    • 133
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    克隆类型
    • 135
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    多克隆
    标记
    • 85
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    This FLT1 antibody is un-conjugated
    应用范围
    • 103
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    Western Blotting (WB)
    特异性
    Peptide: GEHCNKKAVFSRISKFKSTR NDSTTQSNVKH.
    产品特性
    Chromosomal location: 13q12
    Produced from sera of rabbits immunised with a peptide of the C-terminal end of native human soluble VEGFR-1/Flt-1 (CNKKAVFSRISKFKSTRNDSTTQSNVKH).
    纯化方法
    Anti-human soluble VEGFR-1/Flt-1 was purified by affinity chromatography with immobilized Protein A.
    亚型
    IgG
    Top Product
    Discover our top product FLT1 Primary Antibody
  • 应用备注
    Western Blot: use 1-5 µg/mL
    说明

    Rabbit IG Polyclonal Antibody

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
    缓冲液
    PBS
    注意事项
    Centrifuge vial prior to opening.
    储存条件
    -20 °C
    储存方法
    The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
    有效期
    6 months
  • 抗原
    FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
    别名
    VEGFR-1/Flt-1 (FLT1 产品)
    别名
    FLT antibody, FLT-1 antibody, VEGFR-1 antibody, VEGFR1 antibody, FLT1 antibody, flt1b antibody, sFlt1 antibody, AI323757 antibody, Flt-1 antibody, fms related tyrosine kinase 1 antibody, FMS-related tyrosine kinase 1 antibody, vascular endothelial growth factor receptor 1 antibody, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody, FMS-like tyrosine kinase 1 antibody, vascular endothelial growth factor receptor-1 antibody, FLT1 antibody, Flt1 antibody, CpipJ_CPIJ012087 antibody, flt1 antibody, FLT-1 antibody
    背景
    Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
    Synonyms: soluble vascular endothelial growth factor receptor-1, soluble FLT1, soluble FLT, soluble VEGF receptor 1
    NCBI登录号
    NM_001159920, NP_001153392
    UniProt
    P17948
    途径
    RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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