CCR5 抗体 (AA 1-22) (PE)
Quick Overview for CCR5 抗体 (AA 1-22) (PE) (ABIN1558086)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
- 
    - 
                                            抗原表位
- AA 1-22
- 
                                            原理
- Anti-Hu CD195 PE
- 
                                            特异性
- The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
- 
                                            交叉反应 (详细)
- Human
- 
                                            纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 
                                            免疫原
- CCR5 peptide (Met1-Lys22) KLH conjugate
- 
                                            亚型
- IgG1 kappa
 
- 
                                            
- 
    
- 
    - 
                                            应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 
                                            限制
- 仅限研究用
 
- 
                                            
- 
    - 
                                            溶解方式
- No reconstitution is necessary.
- 
                                            缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 
                                            储存液
- Sodium azide
- 
                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 
                                            注意事项
- 
                        Do not freeze. 
 Avoid prolonged exposure to light.
- 
                                            储存条件
- 4 °C
- 
                                            储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
 
- 
                                            
- 
    - 
                                            : "Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes."    in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 409-13, (2012)         (PubMed).        
 : "Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5." in: The Journal of biological chemistry, Vol. 282, Issue 51, pp. 36923-32, (2007) (PubMed).
 : "G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37503-15, (2005) (PubMed).
 
 
- 
                                            : "Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes."    in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 409-13, (2012)         (PubMed).        
- 
    - CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
- 
                                            别名
- CD195
- 
                                            背景
- C-C motif chemokine receptor 5,CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.,CKR5, CCR5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
- 
                                            基因ID
- 1234
- 
                                            UniProt
- P51681
- 
                                            途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
 抗原
- 
                    
 
                                     
                                     
                                    