CCR5 抗体 (AA 1-22)
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北京 101111
Quick Overview for CCR5 抗体 (AA 1-22) (ABIN1558080)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-22
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原理
- Anti-Hu CD195 Purified
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特异性
- The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- CCR5 peptide (Met1-Lys22) KLH conjugate
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亚型
- IgG1 kappa
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anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibody
CCR5 适用: 人 IHC (fro) 宿主: 小鼠 Monoclonal 12D1 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibodyCCR5 适用: 人, 大鼠 WB, ELISA, FACS, IHC 宿主: 小鼠 Monoclonal 6G11D1 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 19-34), (N-Term) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 201-300) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibodyCCR5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (pSer336) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) antibodyCCR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) antibodyCCR5 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (Middle Region) antibodyCCR5 适用: 人, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 151-177) antibodyCCR5 适用: 人 WB 宿主: 兔 Polyclonal RB41438 unconjugated
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应用备注
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Western blotting: Do not boil cell lysates prior to SDS-PAGE.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5." in: The Journal of biological chemistry, Vol. 282, Issue 51, pp. 36923-32, (2007) (PubMed).
: "G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37503-15, (2005) (PubMed).
: "Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2190-8, (2003) (PubMed).
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: "Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5." in: The Journal of biological chemistry, Vol. 282, Issue 51, pp. 36923-32, (2007) (PubMed).
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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别名
- CD195
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背景
- C-C motif chemokine receptor 5,CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.,CKR5, CCR5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
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基因ID
- 1234
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UniProt
- P51681
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
抗原
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