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Shugoshin 抗体 (AA 339-367)

This anti-Shugoshin antibody is a 兔 多克隆 antibody detecting Shugoshin in WB. Suitable for 人.
产品编号 ABIN1538328
发货至: 中国

Quick Overview for Shugoshin 抗体 (AA 339-367) (ABIN1538328)

抗原

See all Shugoshin (SGOL1) 抗体
Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

适用

  • 39
  • 5
  • 5
  • 1
  • 1
  • 1

宿主

  • 38
  • 3

克隆类型

  • 39
  • 2
多克隆

标记

  • 26
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Shugoshin antibody is un-conjugated

应用范围

  • 26
  • 23
  • 7
  • 4
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)

克隆位点

RB36785
  • 抗原表位

    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 339-367

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This SGOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human SGOL1.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    SGOL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

    有效期

    6 months
  • 抗原

    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

    别名

    SGOL1

    背景

    SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

    分子量

    64190

    基因ID

    151648

    NCBI登录号

    NP_001012409, NP_001012410, NP_001012411, NP_001012412, NP_001012413, NP_001186180, NP_001186181, NP_001186182, NP_001186183, NP_001186184, NP_001186185, NP_001186186, NP_612493

    UniProt

    Q5FBB7

    途径

    Maintenance of Protein Location
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