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Shugoshin 抗体 (AA 10-100)

SGOL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7270288
发货至: 中国
  • 抗原 See all Shugoshin (SGOL1) 抗体
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    抗原表位
    • 10
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 10-100
    适用
    • 44
    • 5
    • 5
    • 1
    • 1
    宿主
    • 42
    • 3
    克隆类型
    • 43
    • 2
    多克隆
    标记
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Shugoshin antibody is un-conjugated
    应用范围
    • 30
    • 27
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    原理
    SGOL1 Rabbit pAb
    序列
    SFQDSLEDIK KRMKEKRNKN LAEIGKRRSF IAAPCQIITN TSTLLKNYQD NNKMLVLALE NEKSKVKEAQ DIILQLRKEC YYLTCQLYAL K
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 10-100 of human SGOL1 (NP_612493.1).
    亚型
    IgG
    Top Product
    Discover our top product SGOL1 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    别名
    SGOL1 (SGOL1 产品)
    别名
    sgo1 antibody, NY-BR-85 antibody, SGO antibody, Sgo1 antibody, 3300001M08Rik antibody, C81037 antibody, shugoshin 1 antibody, shugoshin centromeric cohesion 1 antibody, shugoshin 1 L homeolog antibody, Sgo1 antibody, sgo1 antibody, sgo1.L antibody, SGO1 antibody
    背景
    The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.,SGO1,CAID,NY-BR-85,SGO,SGOL1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centromere,SGOL1
    分子量
    24kDa/29kDa/31kDa/33kDa/35kDa/60kDa/64kDa
    基因ID
    151648
    UniProt
    Q5FBB7
    途径
    Maintenance of Protein Location
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