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- 抗原 See all Shugoshin (SGOL1) 抗体
- Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Shugoshin antibody is un-conjugated
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应用范围
- Immunofluorescence (IF)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of human SGOL1 (NP_612493.1).
- 亚型
- IgG
- Top Product
- Discover our top product SGOL1 Primary Antibody
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anti-Shugoshin 1 (SGOL1) (AA 1-292) antibody
SGOL1 适用: 人 ELISA, WB, IP 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Shugoshin 1 (SGOL1) (AA 260-439) antibodySGOL1 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) antibodySGOL1 适用: Schizosaccharomyces pombe WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) antibodySGOL1 适用: Schizosaccharomyces pombe WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 1-292) antibodySGOL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 10-100) antibodySGOL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (Internal Region) antibodySGOL1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 1-292) antibodySGOL1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (N-Term) antibodySGOL1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Shugoshin 1 (SGOL1) (AA 395-444) antibodySGOL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
- 别名
- SGOL1 (SGOL1 产品)
- 别名
- sgo1 antibody, NY-BR-85 antibody, SGO antibody, Sgo1 antibody, 3300001M08Rik antibody, C81037 antibody, shugoshin 1 antibody, shugoshin centromeric cohesion 1 antibody, shugoshin 1 L homeolog antibody, Sgo1 antibody, sgo1 antibody, sgo1.L antibody, SGO1 antibody
- 背景
- The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
- 基因ID
- 151648
- UniProt
- Q5FBB7
- 途径
- Maintenance of Protein Location
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