F12 抗体 (Cleaved-Arg372)
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北京 101111
Quick Overview for F12 抗体 (Cleaved-Arg372) (ABIN1536117)
抗原
See all F12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 323-372, Cleaved-Arg372
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原理
- Cleaved-Factor XII HC (R372) Antibody
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特异性
- Cleaved-Factor XII HC (R372) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to R372.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human FA12. AA range:323-372
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亚型
- IgG
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anti-Coagulation Factor XII (F12) antibody
F12 适用: 人 ELISA, IHC, IP, IHC (p), IEP 宿主: 山羊 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (C-Term) antibodyF12 适用: 人, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 352-587) antibodyF12 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 400-615) antibodyF12 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 191-300) antibodyF12 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 3A3 unconjugated
anti-Coagulation Factor XII (F12) (Heavy Chain) antibodyF12 适用: 人 WB, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) antibodyF12 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 7-34), (N-Term) antibodyF12 适用: 人 WB 宿主: 兔 Polyclonal RB24396 unconjugated
anti-Coagulation Factor XII (F12) (N-Term) antibodyF12 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 486-600) antibodyF12 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- F12 (Coagulation Factor XII (F12))
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背景
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Synonyms: F12, Coagulation factor XII, Hageman factor, HAF
Background: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat
Gene Name: F12
Protein Name: Coagulation factor XII
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分子量
- 41 kDa
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基因ID
- 2161
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OMIM
- 610619
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UniProt
- P00748
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途径
- Complement System
抗原
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