RENT1/UPF1 抗体 (AA 299-348)
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Quick Overview for RENT1/UPF1 抗体 (AA 299-348) (ABIN1535287)
抗原
See all RENT1/UPF1 (UPF1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 299-348
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原理
- Rent1 Antibody
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特异性
- Rent1 Polyclonal Antibody detects endogenous levels of Rent1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human UPF1. AA range:299-348
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))
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别名
- UPF1
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背景
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Synonyms: UPF1, KIAA0221, RENT1, Regulator of nonsense transcripts 1, ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, NORF1, Up-frameshift suppressor 1 homolog, hUpf1
Background: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Gene Name: UPF1
Protein Name: Regulator of nonsense transcripts 1
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分子量
- 124 kDa
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基因ID
- 5976
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OMIM
- 601430
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UniProt
- Q92900
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途径
- SARS-CoV-2 Protein Interactome
抗原
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