RAD50 抗体 (AA 681-730)
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北京 101111
Quick Overview for RAD50 抗体 (AA 681-730) (ABIN1534488)
抗原
See all RAD50 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 681-730
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原理
- Rad50 Antibody
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特异性
- Rad50 Polyclonal Antibody detects endogenous levels of Rad50 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human RAD50. AA range:681-730
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))
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别名
- RAD50
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背景
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Synonyms: RAD50, DNA repair protein RAD50, hRAD50
Background: RAD50 double strand break repair protein(RAD50) Homo sapiens The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010],
Gene Name: RAD50
Protein Name: DNA repair protein RAD50
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分子量
- 153 kDa
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基因ID
- 10111
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OMIM
- 604040
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UniProt
- Q92878
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途径
- DNA Damage Repair, Protein targeting to Nucleus
抗原
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