TP53I3 抗体 (AA 241-290)
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北京 101111
Quick Overview for TP53I3 抗体 (AA 241-290) (ABIN1533944)
抗原
See all TP53I3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 241-290
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原理
- PIG3 Antibody
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特异性
- PIG3 Polyclonal Antibody detects endogenous levels of PIG3 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human QORX. AA range:241-290
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))
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背景
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Synonyms: TP53I3, PIG3, Quinone oxidoreductase PIG3, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein
Background: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: TP53I3
Protein Name: Quinone oxidoreductase PIG3
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分子量
- 35 kDa
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基因ID
- 9540
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OMIM
- 605171
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UniProt
- Q53FA7
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途径
- p53 Pathway
抗原
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