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CSK 抗体 (AA 31-80)

This 兔 多克隆 antibody specifically detects CSK in WB, ELISA 和 IF. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN1533726
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CSK 抗体 (AA 31-80) (ABIN1533726)

抗原

See all CSK 抗体
CSK (C-Src tyrosine Kinase (CSK))

适用

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人, 小鼠, 大鼠

宿主

  • 116
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兔

克隆类型

  • 105
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多克隆

标记

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This CSK antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF)
  • 抗原表位

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    AA 31-80

    原理

    Csk Antibody

    特异性

    Csk Polyclonal Antibody detects endogenous levels of Csk protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from N-ternal human CSK. AA range:31-80

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    CSK (C-Src tyrosine Kinase (CSK))

    别名

    CSK

    背景

    Synonyms: CSK, Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL

    Background: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,

    Gene Name: CSK

    Protein Name: Tyrosine-protein kinase CSK

    分子量

    50 kDa

    基因ID

    1445

    OMIM

    124095

    UniProt

    P41240

    途径

    TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
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