FEN1 抗体 (AA 86-135)
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北京 101111
Quick Overview for FEN1 抗体 (AA 86-135) (ABIN1533720)
抗原
See all FEN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 86-135
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原理
- FEN-1 Antibody
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特异性
- FEN-1 Polyclonal Antibody detects endogenous levels of FEN-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human FEN1. AA range:86-135
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亚型
- IgG
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anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 50-380) antibody
FEN1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 适用: 人 WB, IHC, IF, ICC, IP, IHC (p), PLA 宿主: 兔 Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 4-300) antibodyFEN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 4-300) antibodyFEN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 小鼠 Monoclonal 6F3F2 unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 4-300) antibodyFEN1 适用: 人, 小鼠 WB, IHC, IF, ICC, FACS 宿主: 小鼠 Monoclonal 7D11D7 unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Monoclonal 4D9 unconjugated Recombinant Antibody
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyKD Validated FEN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4835 unconjugated Recombinant Antibody
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 243-272) antibodyFEN1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB17639 unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
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别名
- FEN1
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背景
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Synonyms: FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1
Background: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage byThe protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions
Gene Name: FEN1
Protein Name: Flap endonuclease 1
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分子量
- 42 kDa
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基因ID
- 2237
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OMIM
- 600393
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UniProt
- P39748
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途径
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
抗原
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