LRP1 抗体 (AA 4486-4535)
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北京 101111
Quick Overview for LRP1 抗体 (AA 4486-4535) (ABIN1533132)
抗原
See all LRP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4486-4535
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原理
- LRP1 Antibody
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特异性
- LRP1 Polyclonal Antibody detects endogenous levels of LRP1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human CD91. AA range:4486-4535
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
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别名
- CD91
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背景
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Synonyms: LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91
Background: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015],
Gene Name: LRP1
Protein Name: Prolow-density lipoprotein receptor-related protein 1
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分子量
- 504 kDa
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基因ID
- 4035
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OMIM
- 107770
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UniProt
- Q07954
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途径
- Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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