Topoisomerase II alpha 抗体 (pThr1343)
Our Local Distributor
北京 101111
Quick Overview for Topoisomerase II alpha 抗体 (pThr1343) (ABIN1532096)
抗原
See all Topoisomerase II alpha (TOP2A) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1311-1360, pThr1343
-
原理
- Topo IIα (phospho Thr1343) Antibody
-
特异性
- Phospho-Topo IIα (T1343) Polyclonal Antibody detects endogenous levels of Topo IIα protein only when phosphorylated at T1343.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
纯度
- > 95 %
-
免疫原
- The antiserum was produced against synthesized peptide derived from human TOP2A around the phosphorylation site of Thr1343. AA range:1311-1360
-
亚型
- IgG
-
-
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1352-1493) antibody
TOP2A 适用: 人, 小鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal TOP2A-1361 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1100-1530) antibodyTOP2A 适用: 人, 大鼠 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 6C12G12 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) antibodyKD Validated TOP2A 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB1915 unconjugated Recombinant Antibody
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) antibodyTOP2A 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1435-1531) antibodyTOP2A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E2 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 650-700) antibodyTOP2A 适用: 人, 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR358N unconjugated Recombinant Antibody
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 650-700) antibodyTOP2A 适用: 人, 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR358N unconjugated Recombinant Antibody
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1100-1530) antibodyTOP2A 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6D4B2 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1167-1196), (C-Term) antibodyTOP2A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB24346 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (Middle Region) antibodyTOP2A 适用: 人 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
-
别名
- TOP2A
-
背景
-
Synonyms: TOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme
Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
Gene Name: TOP2A
Protein Name: DNA topoisomerase 2-alpha
-
分子量
- 174 kDa
-
基因ID
- 7153
-
OMIM
- 126430
-
UniProt
- P11388
-
途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
抗原
-
