Retinoblastoma Protein (Rb) 抗体 (pSer608)
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Quick Overview for Retinoblastoma Protein (Rb) 抗体 (pSer608) (ABIN1532026)
抗原
See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 581-630, pSer608
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原理
- Rb (phospho Ser608) Antibody
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特异性
- Phospho-Rb (S608) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S608.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser608. AA range:581-630
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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背景
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Synonyms: RB1, Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Gene Name: RB1
Protein Name: Retinoblastoma-associated protein
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分子量
- 106 kDa
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基因ID
- 5925
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OMIM
- 109800
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UniProt
- P06400
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途径
- Mitotic G1-G1/S Phases
抗原
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