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BRCA1 抗体 (AA 120-220)

Name: BRCA1 抗体 (AA 120-220)
Brand: antibodies-online
SKU: ABIN1512646
Availability: OutOfStock

This anti-BRCA1 antibody is a 兔多克隆 antibody detecting BRCA1 in WB 和 IHC. Suitable for 人. This Primary Antibody has been cited in 2+ publications.

Western blot analysis of extracts of various cell lines, using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

Immunofluorescence analysis of A549 cell using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

Immunohistochemistry of paraffin-embedded human prostate using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

IHC (p)

Immunohistochemistry of paraffin-embedded mouse brain using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

IHC (p)

Immunohistochemistry of paraffin-embedded human breast cancer using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

IHC (p)

Immunofluorescence analysis of A549 cells using BRCA1 antibody. (BRCA1 抗体 (AA 120-220))

9 images

(2 references)

产品编号 ABIN1512646

发货至: 中国

Quick Overview for BRCA1 抗体 (AA 120-220) (ABIN1512646)

抗原

See all BRCA1 抗体

BRCA1 (Breast Cancer 1 (BRCA1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This BRCA1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

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AA 120-220

序列

DEVSIIQSMG YRNRAKRLLQ SEPENPSLQE TSLSVQLSNL GTVRTLRTKQ RIQPQKTSVY IELGSDSSED TVNKATYCSV GDQELLQITP QGTRDEISLD S

交叉反应

人, 小鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

A synthetic peptide corresponding to a sequence within amino acids 120-220 of human BRCA1 (NP_009225.1).

亚型

IgG
anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibody
BRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (pSer1423) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibody
BRCA1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibody
BRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibody
BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1314-1600), (AA 1314-1864) antibody
BRCA1 适用: 人 WB, IF, IP, FACS, ICC 宿主: 小鼠 Monoclonal RAY unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 64-160) antibody
BRCA1 适用: 大鼠, 小鼠 ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (pSer1524) antibody
BRCA1 适用: 人 ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1524-1781) antibody
BRCA1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IHC,1:50 - 1:200

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Yin, Liu, Peng, Peng, Yu, Gao, Yuan, Zhu, Cao, He, Gong, Sun, Fan, Li: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).

Penn, Yang, Zong, Lim, Cole, Yang, Baker, Goonewardena, Buckanovich: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." in: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).
抗原

BRCA1 (Breast Cancer 1 (BRCA1))

别名

BRCA1

背景

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.,BRCA1,BRCAI,BRCC1,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,PSCP,RNF53,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,G2/M DNA Damage Checkpoint,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,BRCA1

分子量

7 kDa/78-85 kDa/202-210 kDa

基因ID

672

UniProt

P38398

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus