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CD63 抗体

CD63 适用: 小鼠 FACS, WB 宿主: 大鼠 Monoclonal R5G2 unconjugated
产品编号 ABIN1504148
发货至: 中国
  • 抗原 See all CD63 抗体
    CD63
    适用
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    小鼠
    宿主
    • 75
    • 62
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    大鼠
    克隆类型
    • 95
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    单克隆
    标记
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    This CD63 antibody is un-conjugated
    应用范围
    • 88
    • 61
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    Flow Cytometry (FACS), Western Blotting (WB)
    特异性
    This antibody reacts with mouse CD63.
    纯化方法
    Protein G agarose
    克隆位点
    R5G2
    亚型
    IgG2b
    Top Product
    Discover our top product CD63 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    储存液
    Without preservative
  • 抗原
    CD63
    别名
    CD63 (CD63 产品)
    背景
    CD63 is not only expressed on activated platelets, but also activated monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and translocated to cell surface upon various stimuli. The membrane of lytic granules in CTLs contains CD63/LAMP-3 and other lysosomal-associated glycoproteins (LAMPs) such as CD107a/LAMP-1 and CD107b/LAMP-2. LAMPs have b een observed on the cell surface as a result of degranulation. CD63 belongs to a member of the tetraspanin transmembrane-protein (TM4) superfamily, which includes CD9, CD37, CD53, CD81, CD82, CD151 and CD231. Several members of this family form noncovalent associations with integrins, particularly ß 1 integrins (CD29), and modulate cellular adhesion properties. CD63 has a tyrosine-based internalization motif in the cytoplasmic C-terminal tail and interacts with adaptor protein complexes such as AP-2 and AP-3. Because AP-2 and AP-3 are involved in facilitating the clathrin-mediated endocytosis, CD63 could be directly involved in the internalization of its membrane protein partners.Synonyms: Granulophysin, ME491, MLA1, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, TSPAN30, Tetraspanin-30
    基因ID
    12512
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