MICA 抗体 (AA 204-253)
Our Local Distributor
北京 101111
Quick Overview for MICA 抗体 (AA 204-253) (ABIN1453404)
抗原
See all MICA 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 204-253
-
原理
- HLA Class I Antibody
-
特异性
- The antibody detects endogenous HLA Class I protein
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- The antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253
-
亚型
- IgG
-
-
-
-
应用备注
- WB 1:500-2000, ELISA 1:10000-20000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
-
别名
- HLA Class I
-
背景
-
Synonyms: HLA-A HLAA
Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans
Gene Name: HLA-A HLAA
Protein Name: major histocompatibility complex, class I
-
分子量
- 40 kDa
-
OMIM
- 142800
-
UniProt
- P04439
-
途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
-