JAK2 抗体 (pTyr119)
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北京 101111
Quick Overview for JAK2 抗体 (pTyr119) (ABIN1450428)
抗原
See all JAK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 81-130, pTyr119
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原理
- JAK2 (phospho Tyr119) Antibody
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特异性
- Phospho-JAK2 (Y119) Polyclonal Antibody detects endogenous levels of JAK2 protein only when phosphorylated at Y119.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr119. AA range:81-130
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亚型
- IgG
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应用备注
- IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- JAK2 (Janus Kinase 2 (JAK2))
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别名
- JAK2
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背景
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Synonyms: JAK2, Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2
Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008],
Gene Name: JAK2
Protein Name: Tyrosine-protein kinase JAK2
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分子量
- 130 kDa
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基因ID
- 3717
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OMIM
- 147796
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UniProt
- O60674
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途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
抗原
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