Optimal working dilution should be determined by the investigator.
限制
仅限研究用
浓度
1.0 mg/mL
缓冲液
PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
储存液
Without preservative
注意事项
Avoid repeated freezing and thawing.
储存条件
-20 °C
储存方法
Upon receipt, store (in aliqouts) at -20 °C.
抗原
KPNB1
(Karyopherin (Importin) beta 1 (KPNB1))
别名
NTF97
背景
Importin ß (karyopherin ß/PTAC97) forms a complex with importin a that is required for classical import of proteins across the nuclear envelope through the nuclear pore complex. Importin a acts as a bridge between the nuclear localization sequence (NLS) and importin ß, while importin ß is the site of initial docking to the pore and is responsible for transport of the target protein into the nucleus. Inside the nucleus, Ran-GTP binds to importin ß, resulting in dissociation of the ternary complex, and importin a and ß are independently recycled back into the cytoplasm. Recently some NLS-containing proteins have been shown to bind directly to importin ß and enter the nucleus in an importin a independent manner.Synonyms: Importin subunit beta-1, Importin-90, KPNB1, Nuclear factor P97