KPNB1 抗体
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Quick Overview for KPNB1 抗体 (ABIN1449199)
抗原
See all KPNB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects Importin β.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Protein G agarose
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免疫原
- Recombinant full-length mouse importin beta
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Upon receipt, store (in aliqouts) at -20 °C.
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- KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))
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别名
- NTF97
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背景
- Importin ß (karyopherin ß/PTAC97) forms a complex with importin a that is required for classical import of proteins across the nuclear envelope through the nuclear pore complex. Importin a acts as a bridge between the nuclear localization sequence (NLS) and importin ß, while importin ß is the site of initial docking to the pore and is responsible for transport of the target protein into the nucleus. Inside the nucleus, Ran-GTP binds to importin ß, resulting in dissociation of the ternary complex, and importin a and ß are independently recycled back into the cytoplasm. Recently some NLS-containing proteins have been shown to bind directly to importin ß and enter the nucleus in an importin a independent manner.Synonyms: Importin subunit beta-1, Importin-90, KPNB1, Nuclear factor P97
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分子量
- 96 kDa
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基因ID
- 3837
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NCBI登录号
- NP_002256
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UniProt
- Q14974
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途径
- Protein targeting to Nucleus
抗原
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