CCR5 抗体
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Quick Overview for CCR5 抗体 (ABIN1449163)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with CD195 antigen.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Ammonium sulfate precipitation followed by gel filtration through Superdex 200 in PBS
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免疫原
- Syngeneic human CD195 transfectants
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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别名
- CD195 / CCR5
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背景
- CD195/CCR5, is a seven transmembrane receptor that is a member of the ß-chemokine receptor family. CCR5 is expressed by T cells and macrophages, and is one of the two major co-receptors for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with resistance to HIV infection, and early infection with HIV-1 is dominated by CCR5-tropic viruses. The ligands of the CCR5 receptor include MCP-2, MIP-1a, MIP-1ß, and RANTES. CCR5 is phosphorylated at specific sites by protein kinase C and GPCR kinase, and data show that two distinct forms of CCR5 protein, 62 and 42 kDa, are present in lymphocytic cells. CCR5 expression was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor
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基因ID
- 1234
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NCBI登录号
- NP_000570
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UniProt
- P51681
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
抗原
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