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TET2 抗体 (AA 1165-1215) (HRP)

TET2 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 兔 Polyclonal HRP
产品编号 ABIN1420648
发货至: 中国
  • 抗原 See all TET2 抗体
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    抗原表位
    • 17
    • 8
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1165-1215
    适用
    人, 小鼠, 大鼠
    宿主
    • 41
    • 8
    • 2
    克隆类型
    • 43
    • 8
    多克隆
    标记
    • 34
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TET2 antibody is conjugated to HRP
    应用范围
    • 40
    • 23
    • 11
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human TET2
    亚型
    IgG
    Top Product
    Discover our top product TET2 Primary Antibody
  • 应用备注
    IHC-P: (1:100-500)
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    Gentamicin sulfate
    注意事项
    This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    别名
    TET2 (TET2 产品)
    别名
    KIAA1546 antibody, MDS antibody, Ayu17-449 antibody, E130014J05Rik antibody, mKIAA1546 antibody, RGD1311625 antibody, tet methylcytosine dioxygenase 2 antibody, TET2 antibody, Tet2 antibody
    背景

    Synonyms: MDS, KIAA1546, Methylcytosine dioxygenase TET2, TET2, Nbla00191

    Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

    基因ID
    54790
    UniProt
    Q6N021
    途径
    Warburg Effect
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