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PMS1 抗体 (AA 245-350) (HRP)

This anti-PMS1 antibody is a 兔 多克隆 antibody detecting PMS1 in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 人.
产品编号 ABIN1417714
发货至: 中国

Quick Overview for PMS1 抗体 (AA 245-350) (HRP) (ABIN1417714)

抗原

See all PMS1 抗体
PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

适用

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宿主

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克隆类型

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多克隆

标记

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This PMS1 antibody is conjugated to HRP

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 245-350

    预测反应

    Human,Mouse,Rat,Cow,Sheep,Horse

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human PMS1

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    注意事项

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

    别名

    PMS1

    背景

    Synonyms: DNA mismatch repair protein PMS1, HNPCC3, hPMS1, Human homolog of yeast mutL, Mismatch repair gene PMSL1, pms1, PMS1 postmeiotic segregation increased 1 S. cerevisiae, PMS1 postmeiotic segregation increased 1, PMS1 protein homolog 1, PMS1_HUMAN, PMSL1, Rhabdomyosarcoma antigen MU RMS 40.10B, Rhabdomyosarcoma antigen MU RMS 40.10E.

    Background: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

    基因ID

    5378
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