COPS7B 抗体 (AA 201-264) (Cy7)
Quick Overview for COPS7B 抗体 (AA 201-264) (Cy7) (ABIN1409766)
抗原
See all COPS7B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-264
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human CSN7b
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亚型
- IgG
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anti-COP9 Signalosome Complex Subunit 7b (COPS7B) (AA 1-157) antibody
COPS7B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-COP9 Signalosome Complex Subunit 7b (COPS7B) (AA 61-95) antibodyCOPS7B 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB56230 unconjugated
anti-COP9 Signalosome Complex Subunit 7b (COPS7B) (AA 1-264) antibodyCOPS7B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-COP9 Signalosome Complex Subunit 7b (COPS7B) (AA 223-257) antibodyCOPS7B 适用: 人 WB 宿主: 兔 Polyclonal RB56231 unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))
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别名
- CSN7b
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背景
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Synonyms: COP9 Complex Homolog Subunit 7b; COP9 Constitutive Photomorphogenic Homolog Subunit 7b; COP9 Signalasome Subunit 7b; COP9 signalosome complex subunit 7b; COPS7B; CSN7B_HUMAN; JAB1 Containing Signalosome Subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b.
Background: The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I˚Bå and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
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途径
- Cell Division Cycle
抗原
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