NFAT5 抗体 (pSer1197)
Quick Overview for NFAT5 抗体 (pSer1197) (ABIN1387082)
抗原
See all NFAT5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer1197
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197
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亚型
- IgG
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anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (AA 1268-1341) antibody
NFAT5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (AA 1-1484) antibodyNFAT5 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (AA 41-298) antibodyNFAT5 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (AA 1422-1531) antibodyNFAT5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H16 unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (Middle Region) antibodyNFAT5 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (AA 1422-1531) antibodyNFAT5 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (pSer155) antibodyNFAT5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (AA 1422-1531) antibodyNFAT5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (C-Term) antibodyNFAT5 适用: 人, 犬, 豚鼠, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (C-Term) antibodyNFAT5 适用: 小鼠, 犬, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))
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别名
- NFAT5
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背景
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Synonyms: NFAT5 phospho S1197, p-NFAT5phospho S1197, Glutamine rich protein H65, KIAA0827, NF AT5, NF-AT5, NFAT 5, NFAT L1, NFAT like protein 1, NFAT5, NFAT5_HUMAN, NFATL 1, NFATL1, NFATZ, Nuclear factor of activated T cells 5, Nuclear factor of activated T cells 5 tonicity responsive, Nuclear factor of activated T cells, Nuclear factor of activated T-cells 5, OREBP, Osmotic response element binding protein, T cell transcription factor NFAT 5, T cell transcription factor NFAT5, T-cell transcription factor NFAT5, TonE binding protein, TonE-binding protein , TonEBP, Tonicity responsive enhancer binding protein, Tonicity-responsive enhancer-binding protein.
Background: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
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基因ID
- 10725
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途径
- RTK signaling, WNT signaling
抗原
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