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NLRP3 抗体 (AA 15-120)

Name: NLRP3 抗体 (AA 15-120)
SKU: ABIN1386361
Availability: OutOfStock

This anti-NLRP3 antibody is a 兔多克隆 antibody detecting NLRP3 in WB, ELISA, IHC (p), FACS, ICC, IHC (fro), IF (p) 和 IF (cc). Suitable for 人, 小鼠, 大鼠和犬. This Primary Antibody has been cited in 11+ publications.

Decreased cAMP exaggerated acute gouty arthritis in P2Y14R-KO rats. (NLRP3 抗体 (AA 15-120))

Antigen: 2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000; TMB staining Read the data in Microplate Reader by 450nm. (NLRP3 抗体 (AA 15-120))

ELISA

Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated (ABIN1386361) at 1:200 followed by conjugation to the secondary antibody and DAB staining (NLRP3 抗体 (AA 15-120))

IHC

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated (ABIN1386361) at 1:200 followed by conjugation to the secondary antibody and DAB staining (NLRP3 抗体 (AA 15-120))

Upregulated cAMP suppressed acute gouty arthritis in vivo. (NLRP3 抗体 (AA 15-120))

Pyroptosis stress was invalidated once cAMP increased by Forskolin in vitro. (NLRP3 抗体 (AA 15-120))

15 images

(11 references)

产品编号 ABIN1386361

发货至: 中国

Quick Overview for NLRP3 抗体 (AA 15-120) (ABIN1386361)

抗原

See all NLRP3 抗体

NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

适用

人, 小鼠, 大鼠, 犬

宿主

兔

克隆类型

多克隆

标记

This NLRP3 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Discover our top product NLRP3 Primary Antibody

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AA 15-120

交叉反应

犬, 人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human NLRP3

亚型

IgG
anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-93), (Pyrin Domain) antibody
NLRP3 适用: 人, 小鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal Cryo-2 unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 671-1033) antibody
NLRP3 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody
Verified NLRP3 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody
NLRP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (N-Term) antibody
NLRP3 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 12-31), (N-Term) antibody
NLRP3 适用: 人, 小鼠, 大鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 30-102) antibody
NLRP3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-100) antibody
NLRP3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B1 unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 21-194) antibody
NLRP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 65-91), (N-Term) antibody
NLRP3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22404 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Li, Jiang, Ye, Zhou, Liu, Yang, Hao, Hu: "P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages." in: Cell death & disease, Vol. 11, Issue 5, pp. 394, (2021) (PubMed).

Yang, Cheng, Liu, Liu, Tan, Guan, Guo, Kuang: "Datura Metel L. Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis and Inhibits Inflammatory Cytokines Production through TLR7/8-MyD88-NF-κB-NLRP3 Inflammasome Pathway." in: Molecules (Basel, Switzerland), Vol. 24, Issue 11, (2019) (PubMed).

Zendedel, Mönnink, Hassanzadeh, Zaminy, Ansar, Habib, Slowik, Kipp, Beyer: "Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury." in: Molecular neurobiology, (2017) (PubMed).

Yu, Liu, Sun, Wang, Wang, Zhao, Dai, Zhao, Zhang, Li, Han, Lu, Dong, Liu, Yu, Li: "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." in: Oncotarget, Vol. 8, Issue 23, pp. 37705-37716, (2017) (PubMed).

Zhang, Pan, Yang, Fu, Liu, Chi, Zhang, Hong, Ma, Yin: "H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 43, Issue 4, pp. 1311-1324, (2017) (PubMed).

Fernandez, Miller, Krammer, Gopal, Greenbaum, Bhardwaj: "Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells." in: Journal of leukocyte biology, Vol. 99, Issue 5, pp. 723-34, (2016) (PubMed).

Zhou, Rivera, Bhosle, Lahaie, Shao, Tahiri, Zhu, Polosa, Dorfman, Beaudry-Richard, Costantino, Lodygensky, Lachapelle, Chemtob: "Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1β." in: The American journal of pathology, Vol. 186, Issue 12, pp. 3100-3116, (2016) (PubMed).

Debye, Schmülling, Zhou, Rune, Beyer, Johann: "Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice." in: Brain pathology (Zurich, Switzerland), (2016) (PubMed).

Heitzer, Kaiser, Kanagaratnam, Zendedel, Hartmann, Beyer, Johann: "Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice." in: Molecular neurobiology, (2016) (PubMed).

Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: "Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model." in: Molecular neurobiology, (2015) (PubMed).

Johann, Heitzer, Kanagaratnam, Goswami, Rizo, Weis, Troost, Beyer: "NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients." in: Glia, (2015) (PubMed).
抗原

NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

别名

CIAS1

背景

Synonyms: NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
Background: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

基因ID

114548

UniProt

Q96P20

途径

Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome