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CD40 抗体

This anti-CD40 antibody is a 小鼠 单克隆 antibody detecting CD40 in FACS, IHC 和 Func. Suitable for 人. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN1383854
发货至: 中国

Quick Overview for CD40 抗体 (ABIN1383854)

抗原

See all CD40 抗体
CD40

适用

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小鼠

克隆类型

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单克隆

标记

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This CD40 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunohistochemistry (IHC), Functional Studies (Func)

克隆位点

B-B20
  • 特异性

    Recognises the Bp50 antigen, a 48 kDa protein

    纯化方法

    Ion exchange chromatography

    过滤

    0.22 μm filtered

    免疫原

    Raji cell line,Myeloma X63/AG.8653 x Balb/c spleen cells

    亚型

    IgG1 kappa

    Biological Activity Comment

    Stimulates B-cell proliferation together with IL-4
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

    储存液

    Without preservative

    储存条件

    4 °C

    储存方法

    Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
  • de Goër de Herve, Durali, Tran, Maigné, Simonetta, Leclerc, Delfraissy, Taoufik: "Differential effect of agonistic anti-CD40 on human mature and immature dendritic cells: the Janus face of anti-CD40." in: Blood, Vol. 106, Issue 8, pp. 2806-14, (2005) (PubMed).

    Durali, de Goër de Herve, Giron-Michel, Azzarone, Delfraissy, Taoufik: "In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment." in: Blood, Vol. 102, Issue 12, pp. 4084-9, (2003) (PubMed).

    Puig-Kröger, Relloso, Fernández-Capetillo, Zubiaga, Silva, Bernabéu, Corbí: "Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells." in: Blood, Vol. 98, Issue 7, pp. 2175-82, (2001) (PubMed).

    Jeannin, Delneste, Lecoanet-Henchoz, Gauchat, Ellis, Bonnefoy: "CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells." in: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15613-9, (1997) (PubMed).

  • 抗原

    CD40

    别名

    CD40

    分子量

    48 kDa

    途径

    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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