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IL-6 Receptor 抗体

Cited in 9+ publications. The 小鼠 单克隆 anti-IL-6 Receptor antibody (Clone B-R6) (ABIN1383672) specifically detects IL-6 Receptor in IHC, IP, ELISA, FACS 和 Func. The antibody is reactive with 人 samples.
产品编号 ABIN1383672
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for IL-6 Receptor 抗体 (ABIN1383672)

抗原

See all IL-6 Receptor (IL6R) 抗体
IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This IL-6 Receptor antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA, Flow Cytometry (FACS), Functional Studies (Func)

克隆位点

B-R6
  • 特异性

    Recognises the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

    纯化方法

    Ion exchange chromatography

    过滤

    0.22 μm filtered

    免疫原

    gp80 transfected CHO cell line,Myeloma X63/AG.8653 x Balb/c spleen cells

    亚型

    IgG1 kappa

    Biological Activity Comment

    Inhibits IL-6 induced proliferation of XG-1 cells
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

    储存液

    Without preservative

    储存条件

    4 °C

    储存方法

    Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
  • Burger, Guenther, Bakker, Schmalzing, Bernand, Baum, Duerr, Hocke, Steininger, Gebhart, Gramatzki: "Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma." in: The hematology journal : the official journal of the European Haematology Association / EHA, Vol. 2, Issue 1, pp. 42-53, (2002) (PubMed).

    Menetrier-Caux, Thomachot, Alberti, Montmain, Blay: "IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells." in: Cancer research, Vol. 61, Issue 7, pp. 3096-104, (2001) (PubMed).

    Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

    Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).

    Menetrier-Caux, Montmain, Dieu, Bain, Favrot, Caux, Blay: "Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor." in: Blood, Vol. 92, Issue 12, pp. 4778-91, (1999) (PubMed).

    Dubois, Barthélémy, Durand, Liu, Caux, Brière: "Toward a role of dendritic cells in the germinal center reaction: triggering of B cell proliferation and isotype switching." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 6, pp. 3428-36, (1999) (PubMed).

    Dubois, Massacrier, Vanbervliet, Fayette, Brière, Banchereau, Caux: "Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 5, pp. 2223-31, (1998) (PubMed).

    Larregina, Morelli, Kolkowski, Sanjuan, Barboza, Fainboim: "Pattern of cytokine receptors expressed by human dendritic cells migrated from dermal explants." in: Immunology, Vol. 91, Issue 2, pp. 303-13, (1997) (PubMed).

    Müller-Newen, Köhne, Keul, Hemmann, Müller-Esterl, Wijdenes, Brakenhoff, Hart, Heinrich: "Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing." in: European journal of biochemistry / FEBS, Vol. 236, Issue 3, pp. 837-42, (1996) (PubMed).

  • 抗原

    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

    别名

    CD126

    背景

    IL-6R / gp80

    分子量

    80 kDa

    途径

    JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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