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CD84 抗体 (PE)

CD84 适用: 人 FACS 宿主: 小鼠 Monoclonal CD84-1-21 PE
产品编号 ABIN1303154
发货至: 中国
  • 抗原 See all CD84 抗体
    CD84
    适用
    • 62
    • 23
    • 16
    • 1
    宿主
    • 49
    • 29
    • 1
    小鼠
    克隆类型
    • 50
    • 28
    • 1
    单克隆
    标记
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    • 2
    • 2
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    • 1
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    This CD84 antibody is conjugated to PE
    应用范围
    • 46
    • 42
    • 25
    • 10
    • 9
    • 6
    • 5
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    • 2
    • 2
    • 2
    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody CD84.1.21 recognizes an extracellular epitope of CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.
    交叉反应 (详细)
    Human
    纯化方法
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    CD84-transfected 300.19 cell line
    克隆位点
    CD84-1-21
    亚型
    IgG2a kappa
    Top Product
    Discover our top product CD84 Primary Antibody
  • 应用备注
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    说明

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    限制
    仅限研究用
  • 溶解方式
    No reconstitution is necessary.
    缓冲液
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    Avoid prolonged exposure to light.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7033-42, (2005) (PubMed).

    Morra, Lu, Poy, Martin, Sayos, Calpe, Gullo, Howie, Rietdijk, Thompson, Coyle, Denny, Yaffe, Engel, Eck, Terhorst: "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells." in: The EMBO journal, Vol. 20, Issue 21, pp. 5840-52, (2001) (PubMed).

    Martin, Romero, de la Fuente, Tovar, Zapater, Esplugues, Pizcueta, Bosch, Engel: "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 7, pp. 3668-76, (2001) (PubMed).

    Sayós, Martín, Chen, Simarro, Howie, Morra, Engel, Terhorst: "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP." in: Blood, Vol. 97, Issue 12, pp. 3867-74, (2001) (PubMed).

  • 抗原
    CD84
    别名
    CD84 (CD84 产品)
    别名
    RGD1564553 antibody, A130013D22Rik antibody, CDw84 antibody, SLAMF5 antibody, LY9B antibody, hCD84 antibody, mCD84 antibody, CD84 molecule antibody, CD84 antigen antibody, Cd84 antibody, CD84 antibody
    背景
    CD84 Molecule,CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.,LY9B, SLAMF5
    基因ID
    8832
    UniProt
    Q9UIB8
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