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PAK4 抗体 (N-Term)

This anti-PAK4 antibody is a 兔 多克隆 antibody detecting PAK4 in WB, IHC (p) 和 IP. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN127123
发货至: 中国
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Quick Overview for PAK4 抗体 (N-Term) (ABIN127123)

抗原

See all PAK4 抗体
PAK4 (P21-Activated Kinase 4 (PAK4))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This PAK4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
  • 抗原表位

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    N-Term

    特异性

    The antibody recognizes 72 kDa Pak4. It does not cross-react with other Paks.

    纯化方法

    Antigen affinity purified

    免疫原

    Synthetic peptide corresponding to the N-terminus of human Pak4
  • 应用备注

    Western Blot: 1 μg/mL. Immunoprecipitation: 20 μg/mL. Immunohistochemistry: 20 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    PBS containing 50 % glycerol, 1 % BSA, and 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C/-80 °C

    储存方法

    Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
  • 抗原

    PAK4 (P21-Activated Kinase 4 (PAK4))

    别名

    PAK4

    背景

    The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region. It has been demonstrated that phosphorylation of serine 474 of PAK4 may play a pivotal role in the activity and function of PAK4 kinase.Synonyms: KIAA1142, PAK 4, PAK-4, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4

    基因ID

    10298

    NCBI登录号

    NP_001014831

    UniProt

    O96013

    途径

    RTK signaling
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