Caspase 12 抗体
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北京 101111
Quick Overview for Caspase 12 抗体 (ABIN127076)
抗原
See all Caspase 12 (CASP12) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The purified antibody detects Procaspase-12 (55 kDa) and cleavage Caspase-12 (36 kDa) on SDS-PAGE Immunoblots.
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纯化方法
- Affinity Chromatography.
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免疫原
- Synthetic peptide corresponding to residues surrounding amino acid 310 of Mouse Caspase-12
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anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 201-300) antibody
CASP12 适用: 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-244) antibodyCASP12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-413) antibodyCASP12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 165-193) antibodyCASP12 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 165-193) antibodyCASP12 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB31705 unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 71-84) antibodyCASP12 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 100-116) antibodyCASP12 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 61-282) antibodyCASP12 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-100) antibodyCASP12 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) antibodyCASP12 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 0.5-4.0 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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缓冲液
- PBS, pH 7.2, containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -20 °C to -70 °C.
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- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
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别名
- Caspase-12
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背景
- Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-Secretase presenilin and beta-Amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.Synonyms: CASP-12, CASP12, Inactive caspase-12
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基因ID
- 12364
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NCBI登录号
- NP_033938
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UniProt
- O08736
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途径
- Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
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