PRKDC 抗体
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北京 101111
Quick Overview for PRKDC 抗体 (ABIN127020)
抗原
See all PRKDC 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The antibody detects a >350,000 kDa and a 180,000 kDa protein (believed to be a processed form of the catalytic subunit), corresponding to the expected molecular weight of DNA-PKcs.
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纯化方法
- Immunoaffinity purified
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免疫原
- Synthetic peptide corresponding to residues surrounding amino acid 4088 of human DNA- PK.
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anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4019-4128) antibody
PRKDC 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibodyPRKDC 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3H6 unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibodyKD Validated PRKDC 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 23GB2055 unconjugated Recombinant Antibody
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibodyPRKDC 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibodyPRKDC 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (pSer2056) antibodyKD Validated PRKDC 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2075 unconjugated Recombinant Antibody
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 151-300) antibodyPRKDC 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4075-4104), (C-Term) antibodyPRKDC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3465-3466 unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibodyPRKDC 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 3899-4128) antibodyPRKDC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 0.5-4 μg/mL. HeLa cell lysate can be used as a positive control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
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别名
- DNA-PKcs / PRKDC / XRCC7
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背景
- DNA-dependent protein kinase (DNA-PK) is made up of 3 subunits, 2 Ku proteins and a large catalytic subunit (DNA-PKcs). DNA-PKcs falls into the phosphatidyl-inositol 3-kinase superfamily although it does have serine/threonine protein kinase activity. This subunit migrates on SDS-PAGE gels as an intact and smaller processed form. In vitro, DNA-PK phosphorylates several transcription factors and other DNA-binding proteins and is believed to play a role in DNA damage recognition, repair and transcription. There is evidence to suggest that DNA-PKcs may be a critical target for proteolysis by a caspase in apoptosis.Synonyms: DNA-dependent protein kinase catalytic subunit, DNPK1, HYRC, HYRC1, p460
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基因ID
- 5591
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NCBI登录号
- NP_001075109
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UniProt
- P78527
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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