ASK1 抗体
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北京 101111
Quick Overview for ASK1 抗体 (ABIN127019)
抗原
See all ASK1 (MAP3K5) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects a 155 kDa human ASK1.
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纯化方法
- Immunoaffinity purified
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免疫原
- Synthetic peptide corresponding to residue surrounding amino acid 1359 of human ASK1.
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应用备注
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Western Blot: 1-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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缓冲液
- PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
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别名
- MEKK5 / ASK1
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背景
- ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas through the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-induced apoptosis.Synonyms: Apoptosis signal-regulating kinase 1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, Mitogen-activated protein kinase kinase kinase 5
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基因ID
- 4217
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NCBI登录号
- NP_005914
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UniProt
- Q99683
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途径
- MAPK Pathway, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
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