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Insulin Receptor 抗体 (Beta Chain)

INSR 适用: 人, 小鼠, 大鼠, 犬 WB, EIA, IHC (fro) 宿主: 小鼠 Monoclonal 9H4 unconjugated
产品编号 ABIN126820
发货至: 中国
  • 抗原 See all Insulin Receptor (INSR) 抗体
    Insulin Receptor (INSR)
    抗原表位
    • 16
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    Beta Chain
    适用
    • 167
    • 95
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    人, 小鼠, 大鼠, 犬
    宿主
    • 165
    • 22
    • 3
    • 1
    小鼠
    克隆类型
    • 158
    • 33
    单克隆
    标记
    • 116
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    This Insulin Receptor antibody is un-conjugated
    应用范围
    • 139
    • 82
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    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    This antibody specifically recognizes the activation loop of Insulin receptor (phosphorylation-independent).
    产品特性
    Synonyms: Insulin Receptor
    纯化方法
    Size Exclusion Chromatography
    组件
    incl. positive Control
    免疫原
    Synthetic peptide conjugated to KLH.
    克隆位点
    9H4
    亚型
    IgG1
    Top Product
    Discover our top product INSR Primary Antibody
  • 应用备注
    Western Blot: 1 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer. Positive Control: Cell lysate from untreated T47D cells. ELISA: 0.1 μg/mL. Immunohistochemistry on frozen sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore with 1 mL H2O (15 min, RT).
    缓冲液
    1 mL2 x PBS containing 0.09 % Sodium Azide, PEG and Sucrose
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C/-80 °C
    储存方法
    Store lyophilized (preferably in a desiccator) at -20 °C and reconstituted (aliquote andfreeze in liquid nitrogen) at -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    Insulin Receptor (INSR)
    别名
    CD220 / INSR (INSR 产品)
    别名
    CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody
    背景
    The insulin receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. The insulin receptor is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional phosphorylation sites such as tyrosine residues 960, 1316, and 1322 regulate the assembly of signal transduction complexes.Synonyms: Insulin Receptor
    基因ID
    3643
    UniProt
    P06213
    途径
    NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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