LRP1 抗体
Quick Overview for LRP1 抗体 (ABIN125958)
抗原
See all LRP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- 8G1 specifically reacts with the 515 kDa α-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocytederived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
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纯化方法
- Protein A affinity chromatography
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免疫原
- Human LRP/alpha2MR.
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亚型
- IgG1
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anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 20-270) antibody
LRP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 20-155) antibodyLRP1 适用: 人 IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3F12E2 unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 4451-4545) antibodyLRP1 适用: 人, 小鼠 ELISA, FACS, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 4441-4544) antibodyLRP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 1-292) antibodyLRP1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) antibodyLRP1 适用: 人 WB, IHC, ELISA, FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal A2Mralpha-2 unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (C-Term) antibodyLRP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (pSer4523) antibodyLRP1 适用: 人, 大鼠 ELISA, FACS, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 692-962) antibodyLRP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 3924-3942) antibodyLRP1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunofluorescence. Immunohistochemistry: 1: 20. Flow cytometry. Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in 1 mL dist. water
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缓冲液
- PBS buffer, pH 7.4 containing 0.5 % BSA
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注意事项
- This product is photosensitive and should be protected from light
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储存条件
- 4 °C
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储存方法
- Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
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别名
- CD91 / LRP1
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背景
- Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1
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基因ID
- 4035
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NCBI登录号
- NP_002323
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UniProt
- Q07954
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途径
- Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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