CTLA4 抗体
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北京 101111
Quick Overview for CTLA4 抗体 (ABIN118890)
抗原
See all CTLA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Highly specific for CD152 (CTAL-4).
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免疫原
- Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig)
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亚型
- IgG2a
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应用备注
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Research studies by Microscopy or Flow cytometry, after in vitro activation of T cells with selected stimuli (Concanavalin A, or solid-phase fixed-CD3 + CD28 Mabs stimulation). Research studies on CTLA-4 expression on B cells and on CTLA-4 expression by Immunohistochemistry only on frozen tissue sections. Fluorescence microscopy or Flow cytometry: 2 μg/5x10e5 cells/test. Cytospin or immunohistochemistry on frozen tissue sections: Working concentration is 5-50 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 1 mL of distilled water.
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缓冲液
- PBS, pH 7.2, containing 1 mg/mL BSA as stabilizer without preservatives
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储存液
- Without preservative
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储存条件
- 4 °C
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储存方法
- Store at 2 - 8 °C.
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- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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别名
- CD152 / CTLA4
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背景
- The cytolytic T-lymphocyte-associated antigen 4 (CTLA-4) is a member of the Ig superfamily (1) and its extracellular domain exhibits a single Ig V-like region. It was originally identified as a fourth cDNA product, during a search for genes that were thought to be specifically expressed in cytotoxic T lymphocytes (1). CTLA-4 has a molecular weight close to 45 kDa (2). It is mainly expressed as a monomer (4), but may also be expressed as a disulfide-linked homodimer (2,3). CTLA-4 belongs to the CD28 receptor family (4,5).Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
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基因ID
- 1493
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NCBI登录号
- NP_001032720
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UniProt
- P16410
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途径
- Cancer Immune Checkpoints
抗原
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