BMI1 抗体 (AA 252-264)
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Quick Overview for BMI1 抗体 (AA 252-264) (ABIN118020)
抗原
See all BMI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 252-264
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特异性
- This affinity purified antibody is directed against human Bmi1 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse, Rat, Orangutan, Canine, Chimpanzee, Froq, Bovine, Cat, Xenopus and Chicken.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide corresponding to amino acids 252-264 of Human Bmi1 protein.
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anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibody
BMI1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3E3 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 120-326) antibodyBMI1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人, 小鼠 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal BMI1-2823 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibodyBMI1 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB22858 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 1-326) antibodyBMI1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E10-1C5 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal BMI1-2689 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) antibodyKD Validated BMI1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB685 unconjugated Recombinant Antibody
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 142-326) antibodyBMI1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal BMI1-2690 unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 257-286) antibodyBMI1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) (AA 61-160) antibodyBMI1 适用: 人 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/5,000-1/30,000Western blot: 1/500-1/3,000. Expect a band approx. 37 kDa in size corresponding to Bmi1 in theappropriate cell lysate or extract. Immunohistochemistry on Paraffin Sections: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.9 mg/mL
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缓冲液
- 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, with 0.01 % (w/V) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
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别名
- BMI-1 / RNF51
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背景
- The Bmi-1 oncogene (also known as polycomb group ring finger 4, MGC12685, murine leukemia viral (bmi 1) oncogene homolog, oncogene BMI 1, polycomb complex protein BMI 1 and RNF51) induces telomerase activity and immortalizes human mammary epithelial cells. Bmi-1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. The polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
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基因ID
- 100532731
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NCBI登录号
- NP_001190991
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UniProt
- P35226
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途径
- Cell Division Cycle, Autophagy
抗原
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