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Caspase 2 抗体 (N-Term)

Name: Caspase 2 抗体 (N-Term)
SKU: ABIN118007
Availability: OutOfStock

The 兔多克隆 anti-Caspase 2 antibody is suitable to detect Caspase 2 in samples from 小鼠和大鼠. It has been validated for WB 和 EIA.

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产品编号 ABIN118007

发货至: 中国

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Quick Overview for Caspase 2 抗体 (N-Term) (ABIN118007)

抗原

See all Caspase 2 (CASP2) 抗体

Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

适用

小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Caspase 2 antibody is un-conjugated

应用范围

Western Blotting (WB), Enzyme Immunoassay (EIA)

Discover our top product CASP2 Primary Antibody

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N-Term

序列

M-A-A-S-S-G-R-S-Q-S-S-L-H-R-K-G-L-C-KLH

特异性

This affinity purified antibody is directed against rat and mouse caspase-2. The antibody detects long and short forms of the protein. Antiserum was purified against the immunizing peptide. This antibody reacts with mouse and rat caspase-2, but not caspase-2 from human sources. Cross reactivity with caspase-2 from other sources has not been determined. Rat and mouse caspase-2 show 94 % homology. There is no significant homology to the human form.

纯化方法

Immunoaffinity chromatography.

免疫原

A synthetic peptide corresponding to the N-terminus of rat Caspase-2 protein conjugated to Keyhole Limpet Hemocyanin (KLH) through a cysteine residue linker.
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 334-452) antibody
CASP2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 153-452) antibody
CASP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) antibody
CASP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3D4 unconjugated Recombinant Antibody

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) antibody
KD Validated CASP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3305 unconjugated Recombinant Antibody

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) antibody
KD Validated CASP2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4375 unconjugated Recombinant Antibody

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 417-439), (C-Term) antibody
CASP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (cleaved), (Internal Region) antibody
CASP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 2-452) antibody
CASP2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 121-220) antibody
CASP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (Internal Region) antibody
CASP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

This product was assayed against 1.0 g of immunizing peptide in a standard sandwichELISA using HRP conjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat) and TMB as asubstrate for 30 minutes at room temperature. A working dilution of 1: 2,000 to 1: 10,000 issuggested for this product. This affinity purified polyclonal antibody was tested by immunoblotting and was found tobe reactive with 48 kDa mouse and rat caspase-2. A control and rat caspase-2 transfected human 293 cell lysate was used to show by

限制

仅限研究用
浓度

0.67 mg/mL (by UV absorbance at 280 nm)

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 2-8 °C.
抗原

Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

别名

Caspase-2

背景

Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer and other diseases. Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. Caspase-2 has been called ICH-1 in human, CED-3 in C.elegans and NEDD-2 in mouse. Caspase-2 is synthesized as an inactive precursor that is processed in cells undergoing apoptosis. The precursor form of all caspases is composed of a pro-domain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli, including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. Caspase-2 is activated in vitro by caspase-1, caspase-3 and granzyme B. Caspase-2 functions as an upstream apoptosis initiator that participates in the activation of downstream caspases, such as caspase-3, caspase-6 and caspase-7. Caspase-2 is highly expressed in embryonic mouse brain but not in adult neural tissue. Alternative mRNA splicing produces a long (48 kDa) and short (35 kDa) form of caspase-2. These forms show tissue specificity and function either as inducers or suppressors of apoptosis. Mature caspase-2 is 435 amino acids in length cleaved (~50 kDa) and is cleaved upon activation into 10 and 20 kDa subunits.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2

基因ID

12366

NCBI登录号

NP_031636

UniProt

P29594

途径

Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway