FAK 抗体 (PTK2 Protein tyrosine Kinase 2) (pSer910) (Alexa Fluor 488)

Details for Product anti-PTK2 Antibody No. ABIN1177062, 供应商: Log in to see
抗原
  • FADK
  • FAK
  • FAK1
  • FRNK
  • PPP1R71
  • p125FAK
  • pp125FAK
  • PTK2
  • Fadk
  • mKIAA4203
  • fak
  • fak1a
  • ptk2
  • ptk2a
  • wu:fa18c04
  • zgc:66114
  • CG10023
  • CT28129
  • DFAK
  • DFak
  • DFak56
  • Dfak
  • Dfak56
  • DmFAK
  • Dmel\\CG10023
  • Fak56
  • Fak56D
  • fak56
  • protein tyrosine kinase 2
  • protein tyrosine kinase 2 L homeolog
  • PTK2 protein tyrosine kinase 2
  • protein tyrosine kinase 2ab
  • Focal adhesion kinase
  • PTK2
  • ptk2.L
  • Ptk2
  • ptk2ab
  • Fak
抗原表位
pSer910
80
67
63
51
50
35
28
21
20
16
16
15
15
15
11
10
9
8
8
7
7
6
6
5
5
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
714
465
430
51
26
22
17
11
11
11
10
8
6
4
4
4
3
3
3
1
1
宿主
小鼠
625
114
3
2
1
1
克隆类型 (克隆位点)
单克隆 ()
标记
This FAK antibody is conjugated to Alexa Fluor 488
18
17
16
12
11
11
11
11
11
11
11
11
10
10
4
2
2
2
应用范围
Intracellular Staining (ICS)
520
194
192
142
132
116
65
34
21
9
9
7
6
2
2
选项
Supplier
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Supplier Product No.
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品牌 BD Phosflow™
免疫原 Phosphorylated Human FAK
克隆位点 K73-480
亚型 IgG2b, kappa
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
别名 FAK (PTK2 Antibody 摘要)
背景 Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that associates with integrins in focal adhesions. Its cellular localization is directed by a 125-amino acid sequence at the C terminus called the Focal Adhesion Targeting (FAT) domain, and the phosphorylation state of serine 910 (S910) in the FAT domain may regulate the assembly of focal adhesions. Furthermore, the binding of extracellular matrix ligands to integrins triggers tyrosine phosphorylations near FAK’s kinase domain that increase its kinase activity, and additional tyrosine phosphorylations near proline-rich motifs create binding sites for the SH2 domains of various adaptor proteins. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions regulates FAK’s targeting to focal adhesions, modulates its kinase activity, and initiates intracellular signaling cascades. Thus, studies suggest that FAK may integrate cellular events controlling cell motility, growth, and invasiveness. The K73-480 monoclonal antibody recognizes the phosphorylated S910 of human FAK. The orthologous phosphorylation sites in mouse and rat FAK are S948 and S913, respectively.
途径 Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
样本量 20 μL
限制 仅限研究用
状态 Liquid
缓冲液 Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
有引用在: Schlaepfer, Mitra, Ilic: "Control of motile and invasive cell phenotypes by focal adhesion kinase." in: Biochimica et biophysica acta, Vol. 1692, Issue 2-3, pp. 77-102, 2004 (PubMed).

Ma, Richardson, Schaefer, Parsons: "Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas)." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 1-12, 2001 (PubMed).

Yamakita, Totsukawa, Yamashiro, Fry, Zhang, Hanks, Matsumura: "Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK." in: The Journal of cell biology, Vol. 144, Issue 2, pp. 315-24, 1999 (PubMed).

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