(3 references)-
- 抗原 See all FAK (PTK2) 抗体
- FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
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抗原表位
- pSer910
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FAK antibody is conjugated to PE
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Phosflow™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Phosphorylated Human FAK
- 克隆位点
- K73-480
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product PTK2 Primary Antibody
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anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr397) antibody
PTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 700-800) antibodyPTK2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 798-1041) antibodyPTK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 355-490) antibodyPTK2 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr576) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) antibodyPTK2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) antibodyPTK2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 396-423) antibodyPTK2 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB20775 unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (AA 1-680) antibodyPTK2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-PTK2 Protein tyrosine Kinase 2 (PTK2) (pTyr861) antibodyPTK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 样本量
- 20 μL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "Control of motile and invasive cell phenotypes by focal adhesion kinase." in: Biochimica et biophysica acta, Vol. 1692, Issue 2-3, pp. 77-102, (2004) (PubMed).
: "Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas)." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 1-12, (2001) (PubMed).
: "Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK." in: The Journal of cell biology, Vol. 144, Issue 2, pp. 315-24, (1999) (PubMed).
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: "Control of motile and invasive cell phenotypes by focal adhesion kinase." in: Biochimica et biophysica acta, Vol. 1692, Issue 2-3, pp. 77-102, (2004) (PubMed).
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- 抗原
- FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))
- 别名
- FAK (PTK2 产品)
- 别名
- FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody
- 背景
- Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that associates with integrins in focal adhesions. Its cellular localization is directed by a 125-amino acid sequence at the C terminus called the Focal Adhesion Targeting (FAT) domain, and the phosphorylation state of serine 910 (S910) in the FAT domain may regulate the assembly of focal adhesions. Furthermore, the binding of extracellular matrix ligands to integrins triggers tyrosine phosphorylations near FAK’s kinase domain that increase its kinase activity, and additional tyrosine phosphorylations near proline-rich motifs create binding sites for the SH2 domains of various adaptor proteins. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions regulates FAK’s targeting to focal adhesions, modulates its kinase activity, and initiates intracellular signaling cascades. Thus, studies suggest that FAK may integrate cellular events controlling cell motility, growth, and invasiveness. The K73-480 monoclonal antibody recognizes the phosphorylated S910 of human FAK. The orthologous phosphorylation sites in mouse and rat FAK are S948 and S913, respectively.
- 途径
- Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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