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LAG3 抗体

Cited in 4+ publications. The 小鼠 单克隆 anti-LAG3 antibody (Clone 11E3) (ABIN1169112) specifically detects LAG3 in WB, ELISA, IHC, ICC, IP 和 Func. The antibody is reactive with 人 和 猴 samples.
Pubmed (4 references)
产品编号 ABIN1169112
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for LAG3 抗体 (ABIN1169112)

抗原

See all LAG3 抗体
LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

适用

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人, 猴

宿主

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小鼠

克隆类型

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单克隆

标记

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This LAG3 antibody is un-conjugated

应用范围

  • 74
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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Functional Studies (Func)

克隆位点

11E3
Discover our top product LAG3 Primary Antibody

  • 原理

    anti-LAG-3, mAb (blocking) (11E3)

    特异性

    Recognizes human and monkey LAG-3.

    产品特性

    Monoclonal Antibody. Recognizes human and monkey LAG-3. Isotype: Mouse IgG1. Clone: 1.10E+04. Applications: ELISA, FUNC (Blocking), ICC, IHC, IP, WB. Liquid. In PBS containing 0.02 % sodium azide. Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

    纯化方法

    Purified from concentrated hybridoma tissue culture supernatant.

    纯度

    >95 % (SDS-PAGE)

    内毒素水平

    <0.001EU/μg purified protein or <1EU/mg purified protein (LAL test, Lonza).

    免疫原

    Recombinant human LAG-3.

    亚型

    IgG1
  • anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 500-525) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 500-525) antibody

    LAG3 适用: 人 WB, IHC, ICC, IP, FACS, IF (p), mIF 宿主: 兔 Monoclonal BLR027F unconjugated Recombinant Antibody

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody

    LAG3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21775 unconjugated

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) antibody

    LAG3 适用: 人 WB, IHC, ICC, IP, FACS, IF (p) 宿主: 兔 Monoclonal BLR028F unconjugated Recombinant Antibody

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 66-199) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 66-199) antibody

    LAG3 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4H6A3 unconjugated

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody

    LAG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibody

    LAG3 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8B12E10 unconjugated

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 250-300) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 250-300) antibody

    LAG3 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR261L unconjugated Recombinant Antibody

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibody

    LAG3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibody

    LAG3 适用: 人 WB, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

    anti-Lymphocyte-Activation Gene 3 (LAG3) antibody
    anti-Lymphocyte-Activation Gene 3 (LAG3) antibody

    LAG3 适用: 人 ELISA 宿主: 小鼠 Monoclonal LAG3-3261 unconjugated

  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用

  • 状态

    Liquid

    浓度

    0.5 mg/mL

    缓冲液

    In PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

    储存条件

    4 °C,-20 °C

    储存方法

    +4°C

    -20°C

    Stable for at least 1 year after receipt when stored at -20°C.

    有效期

    12 months
  • Ward, Hall, Cairns, Leggat, Urbaniak, Vickers, Barker: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, (2008) (PubMed).

    Triebel, Hacene, Pichon: "A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors." in: Cancer letters, Vol. 235, Issue 1, pp. 147-53, (2006) (PubMed).

    Huard, Mastrangeli, Prigent, Bruniquel, Donini, El-Tayar, Maigret, Dréano, Triebel: "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5744-9, (1997) (PubMed).

    Huard, Gaulard, Faure, Hercend, Triebel: "Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand." in: Immunogenetics, Vol. 39, Issue 3, pp. 213-7, (1994) (PubMed).

  • 抗原

    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

    别名

    LAG-3

    背景

    Alternate Names/Synonyms: Lymphocyte Activation Gene-3, FDC Protein, CD223

    Product Description: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

    UniProt

    P18627

    途径

    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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